Type 1 Diabetes: Clinical and Experimental
نویسنده
چکیده
Type 1 diabetes should be perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing cells in the pancreatic islets in genetically susceptible individuals. The past 12 months have provided new insights both into the pathogenesis and treatment of this disease. Further evidence has been provided that insulin may be the critical autoantigen in human type 1 diabetes, and the first data indicating that it may be possible to manipulate spontaneous -cell autoimmunity not only in non-diabetic obese (NOD) mice but also in human disease have been generated. Nevertheless there are still issues remaining open both in relation to the development of type 1 diabetes and to its optimal treatment.
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